In the early 1800s, Isobel Gamble leaves Scotland with her husband, Edward, carrying generations of secrets with her. Edward was an apothecary who fell under the spell of opium and racked up more debt that he could pay. It forced them to flee Edinburgh and head to the New World to start a new life. Within days of arriving in Salem, Edward decides to join a departing ship as a medic while leaving Isobel alone and penniless in a new strange country. Isobel is forced to make her way and survive by any means possible.
Isobel tries to use her sewing abilities to make her name for herself in Salem. She crosses path with a young Nathaniel Hawthorne, and she finds herself drawn to him. He is haunted by the sins of his ancestors, who sent innocent women to the gallows. Isobel is a gifted seamstress that is troubled by her own gifts. As the weeks pass and Edward safe returns seems unlikely, Nathaniel and Isobel finds themselves growing closer.